Plasma proteome changes associated with refractory anemia and refractory anemia with ringed sideroblasts in patients with myelodysplastic syndrome
نویسندگان
چکیده
منابع مشابه
Myelodysplastic syndromes: prognostic significance of multilineage dysplasia in patients with refractory anemia or refractory anemia with ringed sideroblasts.
although full irreversible aggregation was impaired.1 But inhibition of full, irreversible aggregation by wortmannin did not impair thromboxane A2 accumulation in response to LIBS6 plus fibrinogen. These data suggest that the close platelet-to-platelet contact that is brought about by platelet aggregation (primary or full) is not sufficient to generate thromboxane A2 and depends on signaling fr...
متن کاملMyelodysplastic syndromes: prognostic significance of multilineage dysplasia in patients with refractory anemia or refractory anemia with ringed sideroblasts
although full irreversible aggregation was impaired.1 But inhibition of full, irreversible aggregation by wortmannin did not impair thromboxane A2 accumulation in response to LIBS6 plus fibrinogen. These data suggest that the close platelet-to-platelet contact that is brought about by platelet aggregation (primary or full) is not sufficient to generate thromboxane A2 and depends on signaling fr...
متن کاملInitially Diagnosed with Acquired Refractory Anemia and Ringed Sideroblasts
X-linked sideroblastic anemia (XLSA) is caused by mutations of the erythroid-specific 6-aminolevulinate synthase gene (ALAS2) resulting in deficient heme synthesis. The characteristic hypochromic, microcytic anemia typically becomes manifest in the first three decades of life. Hematologic response to pyridoxine is variable and rarely complete. We report two unrelated cases of highly pyridoxine-...
متن کاملMolecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis.
We studied patients with myeloid neoplasm associated with ringed sideroblasts and/or thrombocytosis. The combination of ringed sideroblasts 15% or greater and platelet count of 450 x 10(9)/L or greater was found in 19 subjects fulfilling the diagnostic criteria for refractory anemia with ringed sideroblasts (RARS) associated with marked thrombocytosis (RARS-T), and in 3 patients with primary my...
متن کاملProteome Changes in the Plasma of Myelodysplastic Syndrome Patients with Refractory Anemia with Excess Blasts Subtype 2
The goal of this study was to explore the plasma proteome of myelodysplastic syndrome (MDS) patients with refractory anemia with excess blasts subtype 2 (RAEB-2) in comparison to healthy controls. 20 plasma samples were separated with 2D electrophoresis and statistically processed with Progenesis SameSpots software. 47 significantly differing (P < 0.05) spots were observed, and 27 different pro...
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ژورنال
عنوان ژورنال: Proteome Science
سال: 2013
ISSN: 1477-5956
DOI: 10.1186/1477-5956-11-14